AMH induces mesonephric cell migration in XX gonads
نویسندگان
چکیده
منابع مشابه
Meiotic germ cells antagonize mesonephric cell migration and testis cord formation in mouse gonads.
The developmental fate of primordial germ cells in the mammalian gonad depends on their environment. In the XY gonad, Sry induces a cascade of molecular and cellular events leading to the organization of testis cords. Germ cells are sequestered inside testis cords by 12.5 dpc where they arrest in mitosis. If the testis pathway is not initiated, germ cells spontaneously enter meiosis by 13.5 dpc...
متن کاملMesonephric cell migration induces testis cord formation and Sertoli cell differentiation in the mammalian gonad.
In mammals a single gene on the Y chromosome, Sry, controls testis formation. One of the earliest effects of Sry expression is the induction of somatic cell migration from the mesonephros into the XY gonad. Here we show that mesonephric cells are required for cord formation and male-specific gene expression in XY gonads in a stage-specific manner. Culturing XX gonads with an XY gonad at their s...
متن کاملSerum AMH in Physiology and Pathology of Male Gonads
AMH is secreted by immature Sertoli cells (SC) and is responsible for the regression of Müllerian ducts in the male fetus as part of the sexual differentiation process. AMH is also involved in testicular development and function. AMHs are at their lowest levels in the first days after birth but increase after the first week, likely reflecting active SC proliferation. AMH rises rapidly in concen...
متن کاملSexual dimorphism of AMH, DMRT1 and RSPO1 localization in the developing gonads of six anuran species.
In vertebrates, several genes which are differentially expressed in various species, have been implicated in sex determination and gonadal differentiation. We used immunolocalization to study the expression pattern of three proteins AMH, DMRT1, RSPO1 involved in the sexual differentiation of gonads. The pattern of AMH, DMRT1 and RSPO1 expression was analyzed in X. laevis and in five other diver...
متن کاملEarly expression of AMH in chicken embryonic gonads precedes testicular SOX9 expression.
In mammals, anti-Müllerian hormone (AMH) is produced by Sertoli cells from the onset of testicular differentiation and by granulosa cells only after birth. SOX9, a transcription factor related to the testis-determining factor SRY, is expressed in mouse testis 1 day before AMH. To determine the relationship between AMH and SOX9 in birds, we cloned the AMH promoter in search of SOX9 response elem...
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ژورنال
عنوان ژورنال: Molecular and Cellular Endocrinology
سال: 2003
ISSN: 0303-7207
DOI: 10.1016/j.mce.2003.09.021